Year-end Sale % OFF 
Abstract
Regional variations in size and parenchyma echo-texture of the spleen among sickle cell disease (SCD) patients have been documented in various publications. The objectives of this study were to assess the size and parenchyma echo-texture of the spleen of SCD patients and ascertain the relationship of age, height and weight with the spleen sizes. This was a cross sectional study involving 103 each of SCD and age matched control subjects. Aloka ST- 550 -3500 ultrasound machine with 3.5 and 5 MHz convex transducers was used to scan the subjects over a 15 months period (September, 2012 to November, 2013). The age, height and weight of each subject were recorded. The spleen sizes of SCD patients were generally larger than those of the controls (p < 0.05). Abnormal spleen parenchyma of varied appearances was found among the SCD subjects. There were negative correlations between mean spleen sizes and height, weight and age in SCD patients but positive correlations were found between them in the controls. Routine sonographic assessment of spleen size and echo-texture is useful in the management of SCD patients.
Highlights
Haemoglobinopathy is a genetic disorder including sickle cell disease (SCD) and thalassaemia
Each year about 300,000 infants are born with sickle cell disease globally, out of which about 200,000 cases occur in Africa, and 150,000 of these SCD children are born annually in Nigeria alone.[4]
F = Frequency: ICC = Intra class correlation coefficient: ICC (3, 2, 1) = Intra class correlation coefficient between the first, second, and third measurements obtained by each sonographer, otherwise called intra observer error or variation; and between the first measurements obtained by all the sonographers
Summary
Haemoglobinopathy is a genetic disorder including sickle cell disease (SCD) and thalassaemia. The frequency of the carrier state determines the prevalence of SCD at birth.[6] Only the inheritance of a single abnormal gene - sickle cell trait - offers protection against malaria. Regional variations in size and parenchyma echo-texture of the spleen among sickle cell disease (SCD) patients have been documented in various publications. The objectives of this study were to assess the size and parenchyma echo-texture of the spleen of SCD patients and ascertain the relationship of age, height and weight with the spleen sizes. There were negative correlations between mean spleen sizes and height, weight and age in SCD patients but positive correlations were found between them in the controls. Conclusion: Routine sonographic assessment of spleen size and echo-texture is useful in the management of SCD patients
Sign-in/Register to view highlights & summary 
Published Version (
Free)
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
