Sonochimical synthesis, characterization and physicochemical properties of Cu3Mo2O9 graphene-based nanocomposites for antibacterial therapeutic agent with enhanced activity

Abstract

In this study, Cu3Mo2O9 nanoparticles (NPs) were synthesized by ultrasonic technique as a facile method. The effective parameters on properties of products including: sonication time, capping agent and calcination temperature were changed in order to prepare the desired properties including fine particles with homogeny morphologies. The nanoparticles synthesized in the optimum conditions were utilized to prepare graphene quantum dots-based nanocomposites (Cu3Mo2O9/GQDs NCs). Next, antibacterial activities of the prepared products were studied. According to the results, the antibacterial performance of the nanocomposite was better than pristine nanoparticles. It can be interpreted through two mechanisms that both of them are related to the presence of graphene quantum dots: (a) increasing the production of reactive oxygen species (ROS) and (b) increasing the surface area that increases aggregation of nanoparticles on cell walls of bacteria. According to the results, the minimum inhibitory concentration (MIC) and zone of inhibition of Cu3Mo2O9/GQDs NCs were recorded 156.25 μg/ml and 27 mm against Staphylococcus saprophyticu, respectively. Consequently, the prepared nanocomposite can be identified as a promising antibacterial product.