Sonochemically synthesis of 1,4-dihydropyridine derivatives using nano-silica supported tin tetrachloride as a reusable solid acid catalyst

Abstract

A simple and general synthetic method for the synthesis of 1,4-dihydropyridines via three- or four-component condensation of aldehydes, 1,3-dicarbonyl compounds, and ammonium acetate was developed. In this procedure, nano-silica supported tin tetrachloride as an efficient solid acid catalyst was used under sonication condition. Short reaction times, excellent yields, simple work-up and reusability of catalyst are some advantages of this method.