Sonochemical synthesis and crystal structure of copper(II)-based biodegradable antibacterial scaffold

Abstract

A biocompatible Cu-based coordination polymer with the formula [Cu(pdc)2(DMA)2]n (H2pdc = pyridine-2,5-dicarboxylic acid and DMA = dimethylammonium) has been successfully synthesized by the solvothermal (BCP-1) and sonochemical (BCP-2) methods with high efficiency. Single-crystal X-ray diffraction analysis reveals that the compound crystallizes in the triclinic crystal system with space group P1¯. The primary units of the compound form a one-dimensional-coordination polymer due to only 2-carboxylate oxygen atoms of pdc2− ligand coordinated to the Cu centers. The structures of the compounds were also characterized by FT-IR, PXRD, FE-SEM, and TGA analyses. The antibacterial activity of BCP-1 and BCP-2 was evaluated using the agar well diffusion method. BCP-2 showed better antimicrobial activity than BCP-1 due to the larger contact surface between the inhibitor and the microbial colony. Unlike other Cu-based coordination polymers, which have only inhibitory activity against gram-positive strains, this new coordination polymer showed inhibitory activity against both gram-positive and negative bacterial due to the presence of an antibacterial ligand of H2pdc in its structure.