Sonochemical parallel synthesis of novel 1,2,3-triazoles utilizing gold-supported titania catalyst

Abstract

BackgroundA lower carbon society can be achieved with innovative recycling and parallel organic and pharmaceutical synthesis practices that reduce the chemical industry's environmental footprint; this is crucial to fulfilling the principles of green chemistry and engineering. MethodRegioselective azide-alkyne cycloadditions were investigated using heterogeneous catalysts based on gold supported on titania (Au/TiO2) and ultrasonic irradiation. The catalysts were used in the base-free synthesis of 1,2,3-triazoles via azide-alkyne click reactions. The catalyzed azide-alkyne cycloaddition reaction protocol was completed in a short amount of time (5 min) with high product yields in parallel synthesis design Significant findingThe superior catalytic efficacy of Au/TiO2 catalysts for achieving the highest product yield emphasizes the ultimate sympathetic of the catalyst structure and role. The scanning electron microscope (SEM) was used to distinguish the synergetic effect of Au/TiO2 catalysts, and the ultrasound irradiation tool for fresh and spent catalysts. Furthermore, the Heteronuclear Multiple Bond Correlation (HMBC) 2D NMR technique was used as a valuable tool to unambiguously assign the obtained structures.