Sonocatalytic damage of composite TiO2/ZnO powder to bovine serum albumin under ultrasonic irradiation

Abstract

The composite TiO2/ZnO was prepared by mixing nano-sized TiO2 and ZnO powders directly, in the molar proportion of 4:6, followed by heat-treatment at 500°C for 40 min. The products were charactered by powder X-ray diffraction and transmission electron microscopy. The test of sonocatalytic activities of the composite TiO2/ZnO powders was carried out through the damage of bovine serum albumin (BSA). Otherwise, the effects of several factors on the damage of BSA molecules were evaluated by means of UV-vis and fluorescence spectra. It was found that the damage degree was aggravated with the increase of ultrasonic irradiation time and composite TiO2/ZnO addition amount. These research results were of great significance for driving sonocatalytic method to treat tumor in clinic application.