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Abstract
Drug—wax particles were prepared by pouring heated aqueous solutions of surfactants into melted wax which contained dispersed sulfaethylthiadiazole (SETD). The systems then were slowly cooled to room temperature with stirring. The SETD-wax particles were recovered, washed, dried, and sieved into predetermined mesh size ranges. There appeared to be a direct relationship between drug release rate and average theoretical surface area of the SETD-Glycowax S-932 particles in vitro. This relationship was not seen in the SETD-beeswax particles. The dissolution rates of all the mesh ranges of particles studied seemed to be pseudo first order after the first 15min. of testing. SETD-Glycowax S-932, 50- to 60-mesh particles, showed reasonably good prolonged-release properties in an in vivo urinary excretion study.
Published Version
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