Abstract
An inert matrix that is used to control the release of (PTX) was prepared using Eudragit RL100 and RSPM types as matrix forming agent . The matrices were prepared by either dry granulation(slugging) , or wet granulation method using chloroform as a solvent evaporation vehichle. The cumulative release was adjusted by using polyvinylpyrollidone (PVP) or ethylcellulose (EC) polymers .The results indicated that both methods of preparation were valid for incorporation PTX as a sustained release granules .Moreover ,the results revealed that best polymer used was Eudragit RSPM in 3:20 polymer drug ratio .Besides to that , the results indicated that the release profiles were affected by pH- medium , PVP and EC addition as an enhancer or retardant polymer used respectively. As well as to the method of preparation .
 Key words : Pentoxifylline Sustained Retease , Eudragit RS , RL .
Highlights
Tablet dosage form can be defined as a unit dose of medication containing one or more of medicinal agents, with or without diluents, made by molding the mixture in a suitable compressible shape(1).Sustained release dosage form having drug release features based on the time or location designed to accomplish convenience and therapeutic not offered by conventional release form (2).An inert matrix was used to control the drug release, and this can be adjusted by using the enhancers such as microcrystalline cellulose, polyvinylpyrrolidone or surfactants .Eudragit RL100 and RSPM,are methacrylic copolymers introduced as a coating materials with different permeabilities (3), depending on functional ionized or neutral groups .They are commonly used in sustained release dosage forms (4)
On the bases of using PTX as drug of choice in chronic occlusive aterial diseases,it is of a wise candidate drug to be formulated in Sustained release oral dosage form
Materials Pentoxifylline supplied by slovakopharma, Slovenia, Aceton,acetic acid,chloroform,ethylcellulose, PVP,from BDH chemicals,Ltd.Liverpool, England Disodium hydrogen phosphate, HCL ands Lactose from Reidal De Haen Ag Seelz Hanover, Germany (GER), Eudrait RL100 and RSPM, from Rhom pharma GMBH Weiterstadt GER. ,All other reagents were of analytical grade
Summary
Tablet dosage form can be defined as a unit dose of medication containing one or more of medicinal agents, with or without diluents, made by molding the mixture in a suitable compressible shape(1).Sustained release dosage form having drug release features based on the time or location designed to accomplish convenience and therapeutic not offered by conventional release form (2).An inert matrix was used to control the drug release , and this can be adjusted by using the enhancers such as microcrystalline cellulose , polyvinylpyrrolidone or surfactants .Eudragit RL100 and RSPM ,are methacrylic copolymers introduced as a coating materials with different permeabilities (3) , depending on functional ionized or neutral groups .They are commonly used in sustained release dosage forms (4). On the bases of using PTX as drug of choice in chronic occlusive aterial diseases , ,it is of a wise candidate drug to be formulated in Sustained release oral dosage form. The objective of this study is to prepare controlled release PTX matrix tablets , utilizing dry and wet granulation technique by using Eudragit RL and RS types with PVP and EC polymers as enhancer and retardant materials respectively , to control the release of PTX for extended period (6)
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