Abstract
A mutation in a gene in Neurospora crassa leading to a semicolonial growth pattern and a deficiency of NADP-specific glutamate dehydrogenase is reported. The NAD-specific enzyme is not affected. The mutants (referred to as am-morphs) do not show any nutritional requirement nor is the growth pattern altered by addition of supplements in the medium. Addition of L-alanine, L-glutamate, and other α-amino acids to the medium does not result in an appreciable increase in specific activity of the NAD-specific glutamate dehydrogenase. This is due to the inability of amino acids to induce the NAD-specific enzyme, a phenomenon known to occur in the familiar am mutants. A spontaneous revertant of one of these mutants shows a mycelial morphology together with a normal glutamate dehydrogenase.The behavior of am-morphs is discussed in relation to other amination-deficient, mycelial mutants.
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