Some therapeutic effects of herbal based ointment „Dermoplant G„on venous ulcers

Abstract

Venous ulcers (ulcus cruris venosum) are a common chronic disease requiring continuing treatment, significantly influencing patients' way of life. After the first signs like heavy and achy legs, ankle and leg swelling, the disease progresses, and the patient frequently develops leg ulcers, which can become infected. We tested the therapeutic effects of the ointment „Dermoplant G„on the epithelization (reducing the affected area, ulcers score and microbial flora) of venous ulcers in 10 human patients (4 men and 6 women) during 7 weeks. The major components of the ointment were dry water extract of Allii bulbus, dry ethanol extract of Hyperici herba and oil extract of Calendulae flos. The patients were older than 18 years, with ulceration no longer then 2 months or with recurrent ulcers during last 6 months, localized in lower leg. The involved patients did not use any other phytomedicine or supportive therapy. The parameters were evaluated before the treatment (after clinical diagnosis of venous ulcers), and every 2 weeks during the period of 7 weeks. The ulcers score was evaluated on the basis of epithelization, granulation (0-very marked, 1-moderate marked, 2-little marked, 3-no effect), fibrin deposits, exudation and eczema (0-no effect, 1-little expressed, 2-good expressed, 3- very expressed). The percentage of epithelization of venous ulcers was 61,53±28,26 after 7 weeks, without significant effects on microbial flora (Staphylococcus aureus and Pseudomonas aeruginosa). After 7 weeks of treatment, the ulcers score and symptoms score improvement was almost maximal-99,0%. The total score of treatment with „Dermoplant G“ was 86,37% after 7 weeks.