Abstract
This paper discusses several methods for analyzing data emanating from chronic toxicity and safety-efficacy studies in which repeated measurements are obtained on the same subjects at regular intervals throughout a prolonged period of drug administration. The procedures recommended are described in some detail, and a completely worked example is given. In view of the general availability of high-speed data processing facilities, the routine application, where appropriate, of these or similar methods of analysis should significantly reduce the amount of experimentation necessary to detect various treatment effects over time.
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