Abstract
Muscles from 50 dogs were examined at various times after denervation. Electromyography (EMG) studies were made and motor nerve conduction velocities (NCV) measured. In partial denervation a reduced interference pattern was demonstrated in certain cases. In one case, which resembled spinal muscular atrophy in humans, giant motor unit potentials were present. Iii normal relaxed muscle, spontaneous activity was only recorded from the end plate zone. This ‘end plate noise’ was abolished by muscle relaxants. In denervated muscle, fibrillations and positive sharp waves were present in increasing numbers 5-7 days after denervation. After a total nerve lesion the NCV in the distal segment remained normal for 5-7 days when conduction ceased. The evoked muscle action potential decreased in amplitude during this period. These findings and their physiological origins arc discussed.
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