Abstract
1. Whole resting cells of Pseudomonas aeruginosa oxidise 2-aminopurine as well as the 2-methylamino- and 2-dimethylamino derivative at position 8, in contrast to previous observations with mammalian xanthine oxidase. 2. 6-Mercaptopurine is attacked first at C-2, then at C-8. The resulting 6-thiouric acid is degraded further. 3. 6-Mercaptopurine does not inhibit growing cells of P. aeruginosa, but increases production of the bacterial xanthine oxidase. 4. The 3-methyl derivatives of thioxanthines are oxidised at position 8, while 3-methylhypoxanthine is attacked first at C-2. The resulting complex, containing 3-methylxanthine, dissociates before further oxidation to 3-methyluric acid can take place, in contrast to xanthine.
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Schedule a callMore From: Biochimica et Biophysica Acta (BBA) - Specialized Section on Nucleic Acids and Related Subjects
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