Abstract
During the course of high dosage chlorpromazine treatment, the following complications were observed in a group of 43 chronic schizophrenic patients. 1. Epileptic seizures in 23% of the patients related to a high daily and total dosage, but unrelated to blood pressure changes, to liver tests or other side effects. 2. Pyramidal tract lesion in 13% of the patients occurring again at a high daily dosage and receding after discontinuation of the treatment. 3. 75% of the group manifested mild to severe forms of Parkinsonism; neither of the 2 lobotomized patients was thus affected. 4. Vasoconstriction of the retinal vessels and increased blood pressure was found in several cases at the height of the treatment. 5. Leukopenia and erysipelas were encountered; the former more frequently than the latter. Both were related to a high daily dosage.
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