Some relationships in the formation of arterial hypertension in patients with chronic obstructive pulmonarydiseases and influence of calcium antogonists at this process

Abstract

Intracardiac and central hemodynamics, interleukins, nitric oxide levels and nitric oxide synthase, endothelin-1 were studied. We observed 63 patients with chronic obstructive pulmonary disease with hypertension who received combination therapy with pentoxifylline, of whom 32 patients (main group) included felodipine in addition to this therapy. After treatment, there was a decrease of pressure in pulmonary artery and main vessels, which was accompanied by improvement of clinical manifestations of the disease, hemodynamics, increased activity of nitric oxide synthase and reduction of endothelin-1, interleukin-1β, interleukin-6 and tumor necrosis factor. Positive clinical laboratory dynamics were more pronounced in the main observation group than in the comparison one. Keywords: chronic obstructive pulmonary disease, arterial hypertension, endothelial dysfunction, pentoxifylline and felodipine.