Abstract
The regulatory properties of 4 enzymes (homocitrate synthase, α-aminoadipate reductase, saccharopine reductase, saccharopine dehydrogenase) involved in the lysine biosynthesis of Candida utilis were investigated and compared with the regulatory patterns found in other yeast species. The first enzyme of the pathway, homocitrate synthase, is feedback-inhibited by L-lysine. The inhibition is competitive with respect to 2-oxoglutarate (K i = 6.5 mM). Some other amino acids (glutamate, aspartate, leucine, ornithine, norvaline) and lysine analogues are also inhibitors of one or more enzymes. It is shown that the synthesis of the lysine biosynthetic enzymes is not regulated.
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