Abstract

Research ArticleOpen AccessSome primary considerations in the interpretation of the dominant-lethal assay. V A Ray, and M L Hyneck V A Ray Search for more papers by this author and M L Hyneck Search for more papers by this author Published:1 December 1973https://doi.org/10.1289/ehp.730627Cited by:16AboutSectionsPDF ToolsDownload CitationsTrack Citations ShareShare onFacebookTwitterLinked InRedditEmail FiguresReferencesRelatedDetailsCited By Bagri P, Kumar V and Sikka A (2014) An in vivo assay of the mutagenic potential of imidacloprid using sperm head abnormality test and dominant lethal test , Drug and Chemical Toxicology, 10.3109/01480545.2014.966832, 38:3, (342-348), Online publication date: 3-Jul-2015. Zhu S, Zhang J, Liu C, He Q, Vijayalaxmi , Prihoda T, Tong J and Cao Y (2015) Dominant lethal mutation test in male mice exposed to 900MHz radiofrequency fields, Mutation Research/Genetic Toxicology and Environmental Mutagenesis, 10.1016/j.mrgentox.2015.07.004, 792, (53-57), Online publication date: 1-Oct-2015. Ashby J and Clapp M (1995) The rodent dominant lethal assay: a proposed format for data presentation that alerts to pseudo-dominant lethal effects, Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 10.1016/0027-5107(95)00041-G, 330:1-2, (209-218), Online publication date: 1-Aug-1995. Saunders R, Kowalczuk C, Beechey C and Dunford R (2009) Studies of the Induction of Dominant Lethals and Translocations in Male Mice after Chronic Exposure to Microwave Radiation, International Journal of Radiation Biology, 10.1080/09553008814551341, 53:6, (983-992), Online publication date: 1-Jan-1988. Ray V, Kier L, Kannan K, Haas R, Auletta A, Wassom J, Nesnow S and Waters M (1987) An approach to identifying specialized batteries of bioassays for specific classes of chemicals: Class analysis using mutagenicity and carcinogenicity relationships and phylogenetic concordance and discordance patterns 1. composition and analysis of the overall data base a report of phase II of the U.S. environmental protection agency gene-tox program (MTR 07213), Mutation Research/Reviews in Genetic Toxicology, 10.1016/0165-1110(87)90018-2, 185:3, (197-241), Online publication date: 1-May-1987. Russell L and Hunsicker P (1987) Study of the base analog 6-mercaptopurine in the mouse specific-locus test, Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 10.1016/0027-5107(87)90251-X, 176:1, (47-52), Online publication date: 1-Jan-1987. Ehrenberg L (1984) ASPECTS OF STATISTICAL INFERENCE IN TESTING FOR GENETIC TOXICITY Handbook of Mutagenicity Test Procedures, 10.1016/B978-0-444-80519-5.50042-0, (775-822), . Sheu C and Moreland F (2008) Detection of Dominant Lethal Mutation in Mice After Repeated Low-Dose Administration of 6-Mercaptopurine, Drug and Chemical Toxicology, 10.3109/01480548309072463, 6:1, (83-92), Online publication date: 1-Jan-1983. Oakberg E, Crosthwait C and Raymer G (1982) Spermatogenic stage sensitivity to 6-mercaptopurine in the mouse, Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 10.1016/0027-5107(82)90179-8, 94:1, (165-178), Online publication date: 1-May-1982. Moreland F, Sheu C, Springer J and Green S (1981) Effects of prolonged chemical treatment with cyclophosphamide and 6-mercaptopurine in the dominant lethal test system, Mutation Research/Genetic Toxicology, 10.1016/0165-1218(81)90082-3, 90:2, (193-199), Online publication date: 1-Oct-1981. Sykora I, Gandalovičovǎ D and Řezábek K (1979) Absence of noxious effects of selected neuroleptics in dominant-lethal mutagenesis assay, Mutation Research/Genetic Toxicology, 10.1016/0165-1218(79)90090-9, 66:3, (291-299), Online publication date: 1-Mar-1979. Anderson D, McGregor D, Purchase I, Hodge M and Cuthbert J (1977) Dominant-lethal test results with known mutagens in two laboratories, Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 10.1016/0027-5107(77)90007-0, 43:2, (231-246), Online publication date: 1-May-1977. Anderson D, Hodge M and Purchase I (2018) Dominant lethal studies with the halogenated olefins vinyl chloride and vinylidene dichloride in male CD-1 mice, Environmental Health Perspectives, 21, (71-78), Online publication date: 1-Dec-1977. Anderson D, Hodge M and Purchase I (1976) Vinyl chloride: Dominant lethal studies in male CD-1 mice, Mutation Research/Genetic Toxicology, 10.1016/0165-1218(76)90034-3, 40:4, (359-370), Online publication date: 1-Nov-1976. Brewen J (1976) Practical evaluation of mutagenicity data in mammals for estimating human risk, Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 10.1016/0027-5107(76)90070-1, 41:1, (15-24), Online publication date: 1-Nov-1976. Generoso W, Preston R and Brewen J (1975) 6-Mercaptopurine, an inducer of cytogenetic and dominant-lethal effects in premeiotic and early meiotic germ cells of male mice, Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 10.1016/0027-5107(75)90237-7, 28:3, (437-447), Online publication date: 1-Jun-1975. Vol. 6December 1973Metrics About Article Metrics Publication History Originally published1 December 1973Published in print1 December 1973 Financial disclosures License information EHP is an open-access journal published with support from the National Institute of Environmental Health Sciences, National Institutes of Health. All content is public domain unless otherwise noted. Note to readers with disabilities EHP strives to ensure that all journal content is accessible to all readers. However, some figures and Supplemental Material published in EHP articles may not conform to 508 standards due to the complexity of the information being presented. If you need assistance accessing journal content, please contact [email protected]. Our staff will work with you to assess and meet your accessibility needs within 3 working days.

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