SOME POTENTIAL REQUIREMENTS FOR THE FORMATION OF THE GUT MICROBIOTA IN PRETERM INFANTS: PART 1

Abstract

Abnormal microbial colonization of the gut from birth in newborns aff ects growth, development, and health, leading to short- and long-term adverse eff ects. The microbiota of preterm infants diff ers from that of term ones. This is because preterm infants and their mothers have more complicated prenatal and postnatal health conditions and anatomically- functional immaturity of organs and systems depending on gestational age. Maternal conditions, antibiotics, type of feeding, and use of probiotics can signifi cantly aff ect the gut microbiota of preterm infants in the early neonatal period; however, these eff ects decrease with age. Although some factors and processes are diffi cult to intervene or avoid, understanding the potential factors and determinants will help to develop timely strategies to promote a healthy gut microbiota in preterm infants. This review discusses potential determinants of gut microbial colonization in preterm infants,the underlying mechanisms, and recommendations for addressing adverse eff ects.