Some potential antitumor 2,2′-dipyridylamine Pt(II)/Pd(II) complexes with amino acids: Their synthesis, spectroscopy, DNA binding, and cytotoxic studies

Abstract

Four new palladium(II) and platinum(II) complexes of formula [M(dipy)(AA)] + (where dipy is 2,2′-dipyridylamine, AA is an anion of glycine or L-alanine, and M is Pd(II) or Pt(II)) have been synthesized and characterized with amino acids binding as bidentate ligands. These complexes are 1:1 electrolyte in conductivity water. Of the above four complexes, the two L-alanine complexes show ID 50 values against P388 lymphocytic leukemia cells lower than cis-diamminedichloroplatinum(II), whereas the two glycine complexes show ID 50 values higher than cisplatin. The interaction of calf thymus DNA with the above complexes shows significant spectral changes in the presence of [Pt(dipy)(gly)]Cl, [Pd(dipy)(ala)]Cl, and (Pt(dipy)(ala)]Cl and the mode of binding between these complexes and DNA seems to be noncovalent.