Abstract
Anesthetized and non-anesthetized animals were tested with intravenous injections of Heloderma suspectum venom. These envenomated animals—dogs and rats—developed hypotension, tachycardia, and ventilatory difficulties. Gila Monster venom had the immediate effect of causing a reduction in carotid blood flow. This was followed by hypotension and changes in intrathoracic and post-caval blood pressures. Ventilatory irregularities found—such as gasping, rapid shallow breathing, or apnea—were accompanied by a reduction in arterial blood oxygenation. Toxicity studies proved that venom used had an ld 50 of 1·35 mg/kg when tested by means of intracardial injections in rats.
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