Abstract
California scorpionfish venom has a primary muscarinic action on the isolated rat atria and a secondary beta adrenergic stimulating action. The initial effect can be blocked with atropine and inhibited by hemicholinium. The secondary effect is inhibited by pretreatment with reserpine or a beta adrenergic blocking agent. The muscarinic activity is associated with labile components which cause the release of endogenous acetylcholine. The adrenergic effect is due to fractions which release endogenous catecholamines. The venom has little effect on the guinea pig phrenic nerve-diaphragm preparation. Although the venom possesses a mild in vitro direct hemolytic activity no changes were produced in the blood clotting systems studied.
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