Abstract
The effect of five N, N-disubstituted dithiocarbamates on spontaneous activity, penetrazole convulsions, and noradrenaline and dopamine brain levels in mice, and on the amphetamine-induced stereotypy in rats was studied. All the compounds at high dosages depressed the brain noradrenaline content and spontaneous activity. Dimethyldithiocarbamate, diethyldithiocarbamate and ethyldithiocarbanilate elevated the brain dopamine level, whereas dibutyldithiocarbamate and dicyclohexyldithiocarbamate depressed it. Dimethyldithiocarbamate and diethyldithiocarbamate potentiated the convulsive effect of penetrazole whereas ethyldithiocarbanilate exerted a protective effect. Dibutyldithiocarbamate and dicyclohexyldithiocarbamate antagonized the amphetamine-induced stereotypy. The relation between the effect of the dithiocarbamates on brain catecholamines and in pharmacological tests is discussed.
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