Abstract
Abstract An investigation was made of the pharmacological properties of a commercial heart extract (Recosen), said to be of value in the treatment of angina pectoris. This extract increased coronary flow but decreased force of beat in isolated perfused mammalian hearts. It potentiated the pressor effects of adrenaline in the spinal cat whilst not affecting those of noradrenaline, and it antagonised the actions of adrenaline and noradrenaline upon intestinal muscle. A mild anticholinesterase activity was demonstrated on striped muscle. The significance of these findings is discussed.
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