Abstract
Publisher Summary Borna disease (BD) is a chronic encephalomyelitis occurring naturally in horses and sheep. It is characterized by a long incubation period and a progressive development with gradual loss of coordination and certain sensory afflictions. Histopathological lesions are only seen in the nervous system. In the CNS they are characterized by non-purulent meningoencephalitis and myelitis. Perivascular infiltrations in the grey matter are the main changes observed. A necrotizing encephalitis is rarely seen. Some indications on pathogenesis of BD have been obtained in experimentally infected rabbits (unpublished results). Virus specific antigen becomes detectable about 12 days after immune comples (IC) inoculation. This can be seen in the cortex and olfactory bulbs. It spreads to other areas of the brain including the hippocampus, midbrain, and cerebellum. Neurons in the retina, trigeminal ganglia, and the autonomic ganglia also have antigen in the late infection. In addition, cells of the adrenal medulla are also infected.
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