Some of the organic ligand transition metal complexes can serve as potent α-glucosidase inhibitors: in-vitro, kinetics and in-silico studies

Abstract

Inhibition potential of synthesized bi-ligand metal complexes of 4-aminoantipyrine Schiff bases (3–14) and mixed-ligand metal complexes of cysteine-moxifloxacin (15–24) were analyzed for their inhibition potential against α-glucosidase and the type of inhibition was assessed by their kinetics and molecular docking studies. The Hg metal complex of cysteine-moxifloxacin (17) showed promising inhibition. Furthermore, the Ag (14), Hg (6) and Cu (4) metal complexes of Schiff base ligand of 4-aminoantipyrine also presented high activity potential. The IC 50 values of these compounds are 2.36 ± 0.14 μM, 48.8 ± 2.20 μM, 189 ± 17.00 μM and 264 ± 10.00 μM, respectively, as compared to standard drug acarbose with IC50 value of 378.2 ± 0.12 μM. Kinetic studies of compounds (17 and 14) from both series of metal complexes indicated that they are noncompetitive inhibitors of α-glucosidase. Molecular docking studies showed that these compounds accommodate well in the active site of α-glucosidase.