Abstract
Sialic acid in wax-stimulated saliva varied between different individuals and with the same individuals on different occasions. Sialic acid was released from the glycoproteins and metabolised by bacterial action which could be prevented by either antibiotic or heat. Neuraminidase released bound sialic acid from the glycoproteins in sterile saliva. Only trace amounts of sialic acid were present in incubated saliva after 24 hr. Dental plaque contained zero or trace amounts of sialic acid. Buffered glucose retarded both the release and metabolism of sialic acid in saliva. Hexosamines were retained by the glycoproteins in saliva to a much greater extent than was sialic acid and appreciable amounts (0.9 per cent) were found in dental plaque.
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