Abstract
The effects of St 155 [2-(2,6-dichlorophynylamino)-2-imidazoline hydrochloride] were investigated on conditioned salivation and pilocarpine-induced salivation in conscious dogs and on salivation caused by stimulation of the chorda tympani in anaesthetised dogs. St 155 greatly reduced conditioned salivation but did not reduce salivation produced by injecting pilocarpine or stimulating the chorda tympani. The suggestion that St 155 inhibits salivation by an action in the central nervous system is discussed. A central inhibition of salivation would account for the dryness of the mouth encountered as a side effect in the use of the drug as an antihypertensive agent.
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