Abstract
The N-demethylation of three pairs of secondary and tertiary amines by mammalian liver microsomes has been studied. It has been found that the secondary amines have the greater affinity for enzyme, that their demethylation is more difficult to inhibit and that the observed V max values are lower than for the corresponding tertiary amine. Furthermore microsomes from phenobarbital induced rats show a greatly increased demethylation rate for the tertiary amines but not for the corresponding secondary amines. It is not known at present how general these observations are nor is it completely apparent what their meaning is. Nevertheless, these results are reported in the hope that they may be exploited to yield both more information on the nature of the microsomal demethylation system and upon the mechanism of induction.
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