Abstract
Abstract The analysis of different Nifedipine commercial samples indicated the presence of impurities other than the nitroso- and nitrophenylpyridine analogues of Nifedipine generally are included in the pharmacopoeia-monographs. Besides the two latter photodegradation products isonifedipine and a tetrahydropyrimidine derivative as by products of nifedipine-synthesis were identified. HPLC procedure is suitable for the separation Nifedipine and all of the four contaminants is published.
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