Abstract
Hexachlorocyclohexane (HCH), an organochlorinated pesticide used extensively for the protection of crops, has been reported to affect the central nervous system. Attempts have been made to validate the behavioural changes including distance travelled, time resting, stereotypic time, ambulatory time, stereotypic movements and vertical movements in rats treated with HCH (50 mg/kg) and fed on protein deficient diet (5% Casein) for 120 days. Significant (P < 0.001) increase of 5‐HT uptake by platelets was recorded in pesticide exposed animals. Similarly ADP induced aggregatory responses were found to be enhanced significantly (P < 0.001). Bioaccumulation of pesticide in vital organs suggest that insecticide circulate rapidly through the body and can have a rapid and definitive effect. Changes in behaviour and platelets function may also be claimed to the promising sign of neurotoxicity occurring at the lower level of pesticide exposure under the influence of malnutrition.
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