Abstract
The discovery of CFF-DNA originating from the fetus in the plasma of pregnant women has facilitated the development of noninvasive prenatal testing (NIPT) that compensate for surgical tests that are expensive and expose mother and her fetus to danger beside it enable the detection of fetal abnormalities and malformation , especially in pregnant women suffer from problems such as preeclampsia , hypertension, gestational diabetes , and other disorders that increase the chance of having children with defects or problems in fetal differentiation. In this research quantitative real time PCR technology had been used to determine the amplicon's copy number variations, of GATA1 and MDM2 genes between normal and pregnant suffer problem groups that had an important role in the embryonic development and differentiation.
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