Some issues of antibacterial therapy in rheumatology

Abstract

The fight against infectious agents is a topical issue of the day, and treatment of the infectious pathology in rheumatological patients of is often presents a difficult task. The main problems faced by rheumatologists include presence of new pathogens, the role of opportunistic microflora and increased influence of the resistant microorganisms, the issue of the effectiveness and interaction of antibacterial drugs with antirheumatic drugs. All the above listed necessitates the search and development of new schemes and methods of antibiotic therapy in rheumatology. The main diseases associated with bacterial infection include reactive arthritis, Lyme arthritis against the background of Lyme borreliosis, bacterial (septic) arthritis, and others. The authors performed the analysis of literature sources and international recommendations regarding the possibilities of using antibacterial drugs for reactive arthritis, Lyme arthritis and bacterial (septic) arthritis. The current schemes of rational antibacterial therapy are presented. The timely treatment of chlamydial urogenital infection in patients with reactive arthritis plays an important role. The effectiveness of the treatment of the early stages of Lyme arthritis, that is, at the stage of erythema migrans, was noted, which may be the primary prevention of joint damage. Combinations and timing of antibiotic therapy for bacterial (septic) arthritis are highlighted. It should be remembered that a bacterial infection can be a trigger for the development of rheumatological pathology, therefore, the timely use of adequate antibiotic therapy, in some cases, can be considered the primary prevention of certain diseases. Therefore, the development of effective schemes for rational antibiotic therapy and monitoring of infectious agents are urgent problems. Rheumatologists should be aware of new recommendations for the management of patients with infectious diseases and timely prescribe the most effective regimens and therapy programs.