Abstract
Michael reactions of β-keto esters 1a—1h with methyl vinyl ketone (2a) catalyzed by FeCl3 · 6 H2O (5 mol%) proceed with up to 99% yield. Conversion of β-keto esters 1a—1e derived from chiral alcohols with 2a result in only very low diastereoselectivities (max. de 20%). A bis-β-keto ester 1i and a bis-vinyl ketone 2b — both valuable monomers for poly-Michael reactions — are synthesized from common starting materials in up to gram quantities.
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