Abstract
Praomys (Mastomys) natalensis develops a wide variety of autoantibody specificities with age; of these only those to thyroid colloid were associated with a histopathological lesion e.g. thyroiditis. An inverse relationship was found between the mean number of autoantibodies and the occurrence of lymphoreticular tumors. It appears that Mastomys is a better model for studies on the general mechanisms of autoimmunity than for investigating specific autoimmune diseases per se.
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