Abstract
Oestrogen-dependent breast cancers are considered to produce oestradiol in the breast through the initial action of a sulphatase on the oestrone sulphate reservoir, followed by reduction of the oestrone formed by a 17β-hydroxysteroid dehydrogenase. The low rate of incidence of the disease in the Far East has been related to a high dietary intake of soya products containing flavones and isoflavones. We have found that the flavones chrysin (IC50 60-5 μM), apigenin (18-3 μM) and naringenin (19-9 μM), and the isoflavones genistein (195 μM), biochanin A (47-6 μM) and daidzein are potent inhibitors of human placental 17 β-hydroxy steroid dehydrogenase.
Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
