Some features of the influence of nitrogen oxide on humans at rest, physical activity and pathology

Abstract

The literature data on the general characteristics and mechanisms of action of nitric oxide, its role in the regulation of the functioning of the cardiovascular system and the body as a whole are used in the work. The existing NO-dependent mechanism of regulation of vascular reactivity in the conditions of endothelial dysfunction is stated; cGMP-independent mechanism of NO action on calcium homeostasis and sensitivity of smooth muscle myofibrils to calcium ions. Interesting are the results of studies that reflect the importance of nitric oxide in health. Age-related changes in vascular endothelial function due to increasing age and their importance in the development of age-related pathology are shown. Materials that reflect the importance of the use of nitric oxide donors for the treatment of diseases of various body systems, as well as factors of pharmacological correction of disorders of NO metabolism and associated with these changes endothelial dysfunction. Much attention is paid to the work, which reflects the role of nitric oxide in improving physical performance and the importance of this effect in the lives of athletes. The effect of nitric oxide on microorganisms, the use of nitric oxide in the treatment of infectious diseases, in particular during viral infection, is proved. The contribution of Ukrainian scientists in studying the effects of nitric oxide on the body of healthy and sick people, the elderly and senile, as well as the role in the creation of pharmacological drugs, nitric oxide donors for the prevention and treatment of diseases.