Abstract
Publisher Summary In the nervous system, neurons communicate with each other mainly through the use of chemical transmitters. From a simplistic point of view, one could imagine that one excitatory and one inhibitory transmitter would be sufficient for a nervous system to function. However, this does not seem to be true in view of the recent discovery of many peptides in the nervous system. Finding an explanation for this “diversity of transmitters” may provide much insight to understanding of the nervous system. Simple model systems have proven very useful in the past; for instance, the knowledge of synaptic transmission gained from studies of the frog neuromuscular junction seems to apply to fast chemical transmission in general. The study of peptidergic transmission may benefit from a similar strategy. A sufficiently simple preparation may permit a rigorous and detailed characterization of peptidergic transmission.
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