Abstract
INTRODUCTION I.P. Pavlov indicated in the last century that the action of many pharmacological substances begins after their contact with the endings of afferent nerves. Clark was ~he first to carry out quantitative calculations of the action of a phgrmacological substance on a ce~l; he showed that oubain occupies only 3% of frogcardiac cells during the period of maximum effect, l.e° during cardiac arrest. Later, Ari~ns introduced the concepts of affinity of a pharmacological substance for cellular receptors and of its efficiency, or intrinsic activits, independent of the affinity, proportional to the number of receptors occupied by the drug. A number of authors have demonstrated lately the presence, in the structures of the central nervous system~ of receptors specific for some neurotropic drugs, opiate anal~esics included. Pert and Snyder ((973) have shown in experiments on homogenates of the J
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