Abstract
Oliver and Schafer (1) found that extracts of the suprarenal glands when injected intravenously produced a marked rise in blood pressure. Elliott (2) studied the vascular response to epinephrine in great detail and found that the rise in blood pressure following the injection of epinephrine into an animal with the central nervous system destroyed was, within certain limits, directly proportional to the amount injected. Investigations carried out by numerous workers demonstrated that the seat of action of epinephrine was chiefly, at any rate, the nerve endings of the sympathetic system, and that the effect of epinephrine was synonymous with stimulation of the sympathetic nerve supply. The point of action of epinephine was therefore considered to be entirely peripheral. The effect of stimulation of the sympathetic nerve supply to any structure being known, the effect of epinephrine on any organ could be correctly predicted. That epinephine, in addition to its well defined peripheral action, has a central ac...
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