Abstract
Lesions can be produced in many different tissues with ultrasonic irradiation at intensities varying from 1 to 3 watts/sq cm for periods of 1 to 15 minutes. The higher the intensity and the longer the duration of treatment, the more severe were the lesions. Focused ultrasound waves of 37.5 total watts for 5 to 15 minutes produced localized areas of necrosis in liver. Other histologic lesions produced by various intensities and durations of treatment included necrosis, inflammation and edema of skin, subcutaneum, and muscle; degeneration, necrosis and giant cell reaction in testis; necrosis, ulcers, inflammation and hemorrhage in the intestines; and necrosis of bone and hyaline droplet change in renal tubular epithelium. Cavitation, probably due to the accumulation of bubbles of gas, was not observed in livers or other tissues of living animals that were treated. The change was produced in the livers of animals treated in situ after death and in livers removed from the body and treated.
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