Abstract
Summary. Ovaries of 15-day-old mice were cultured in vitro with steroids of the oestrogen biosynthetic pathways. Most steroids stimulated [3H]-thymidine uptake at 1 or 0·1 μg/ml but 100 μg/ml of pregnenolone and 10 μg/ml of testosterone were required. Pregnenolone, testosterone and oestradiol-17β stimulated growth of small follicles but inhibited mitosis in those with three or more layers. The physiological significance of these high steroid levels is briefly discussed and the induced patterns of follicle growth are contrasted with those due to FSH or LH.
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