Abstract
The effect of topically applied RNA precursors on both acquisition and extinction of brightness discrimination was studied. Hippocampal injection of uridine monophosphate (UMP) 30 min prior to onset of training caused a delay in extinction of the learned reaction. The same effect was observed when UMP was injected 1 min after completion of training, whereas hippocampal application of UMP 60 min after completion of training, and injection of UMP into the frontal cortex 30 min before onset of training did not show any influence on the extinction. However, the acquisition capability was not influenced by any of the types of treatment used.
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