Abstract
Reserpine (methylreserpate 3,4,5-trimethoxybenzoic acid ester) is a pure crystalline alkaloid of rauwolfia root ( Rauwolfia serpentina Benth). Known for centuries in India, it was given serious consideration in the 1950's as a hypotensive and later as a tranquilizer. It has been reported to be of great value as an antihypertensive and calming agent for human use (Goodman and Gilman 1956). In tense patients it is especially useful in lowering blood pressure, producing a calming effect, and slowing the pulse rate. It also imparts a sense of well being. In some cases a severe mental depression has been reported from use, and shock therapy is sometimes required to overcome the depression. Some side effects noted are drowsiness, increased frequency of defecation, bizarre dreams, and dizziness (CIBA 1963).
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