Abstract
The effects of pituitary stalk section and of hypophysectomy in rats have been compared. Growth was equally retarded after the two operations and there were excessive deposits of fat in each group of animals.In the thyroid the height of the follicular cells was greatly reduced in the hypophysectomized rats; after stalk section the cell height was less than normal but greater than after hypophysectomy. In both groups of animals the adrenals became greatly atrophied and the width of the cortex was much reduced. Marked atrophy of the gonads occurred after both operations, in males and females. The secondary sex organs also atrophied. There was no significant difference between the effects of the two operations on the adrenals and gonads.The changes in the target organs of the stalk‐sectioned rats are correlated with changes found in the cytology of the surviving areas of the anterior pituitary in these animals.
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Schedule a callMore From: Quarterly journal of experimental physiology and cognate medical sciences
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