Abstract
Embden, Griesback and Schmitz,1 Witzemann,2 Winter and Smith3 and others seem to have demonstrated that phosphates, both organically and inorganically bound, play an important role in carbohydrate metabolism. It thus becomes of interest to know whether inorganic phosphates parenterally administered influence this metabolism as mirrored by blood sugar changes.Our experiments show that when ortho-phosphoric acid (0.2-2.0 cc. U. S. P. acid in 10 cc. water), mono basic sodium phosphate (1.0-4.0 grams dissolved in the least amount of water), dibasic sodium phosphate (0.5-2.0 grams) and the tribasic sodium phosphate (1.0-3.0 grams) are injected subcutaneously in rabbits (weight 1000-1300 grams) the blood sugar practically always shows a very marked rise. The increased sugar is apparent within twenty minutes, and lasts as a rule for two hours or more. Acid sodium phosphate tends to produce the highest blood sugars when compared with the dibasic and tribasic salt on a weight of salt per kilogram body weight basis...
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