Abstract
The gracilis anticus and posticus muscles of albino rats were exposed to a number of common local anesthetic agents. In general, clinically used concentrations of most agents appeared to be specifically destructive of skeletal muscle. Results also suggest that higher concentrations are more generally histotoxic. The sequence of muscle changes after one drug (2% lidocaine) was followed over an extensive time period. Muscle regeneration from single myoblasts was found to be rapid and complete by 2 weeks. Preferential destruction of red- or white-type muscle fibers was observed after many of the agents. The drug effects are discussed relative to the characteristics of mature and immature muscle fibers and the physical properties and biological activities of the local anesthetics.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
