Abstract
In 1929 Corner and I described a method for the preparation of active corpus luteum extracts which seemed to substitute completely for the corpus luteum in so far as its functions were known. These extracts produced progestational proliferation of the endometrium in the castrated rabbit, sensitized the guinea pig's uterus so that deciduomata could be produced experimentally, maintained pregnancy to term in rabbits castrated shortly after mating, and in monkeys produced premenstrual changes in the endometrium. All these responses were produced by relatively crude extracts. Some of them have been produced by progesterone, the pure crystalline principle, but others have not. The purpose of this discussion is to show some of the reasons why progesterone fails to replace completely the crude extracts and to attempt to analyse in part the role which the ovarian hormones play during pregnancy and pseudopregnancy in the rabbit.
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