Abstract
1. 1. The development of genital organs of rats chronically treated with cimetidine showed that the drug may present anti-androgenic activity. 2. 2. This treatment did not alter the sensitivity of vas deferens to noradrenaline, but increased their sensitivity to BaCl 2. 3. 3. In the male reproductive system, cimetidine must have peripheral actions apart from the central ones observed after chronic treatment.
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