Abstract
Adiphenine, benactyzine, and chlorpromazine were studied in four tests of operant behavior: a fixed interval schedule of reinforcement, a variable interval schedule, avoidance conditioning, and a conditioned emotional response. Adiphenine was essentially inactive under all conditions studied. Benactyzine exhibited both rate-increasing and ratedecreasing activity, depending on the dose, the time after administration, and the behavioral test. Chlorpromazine showed a consistent depressant action in all tests, following the usual dose-response relationship.
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