Abstract
The tumor-forming potential of polyoma-transformed mouse cells was found to be diminished but not eliminated after growth in the presence of 5-bromodeoxyuridine (BUdR). Several in vitro characteristics of the cells were also investigated and those which best correlated with the tumor studies were the ability to form colonies either in agar suspension or on monolayers of non-transformed cells. Transformed cells treated with BUdR grew well in culture when plated above a certain critical number of cells per unit area and poorly when plated at lower densities. Non-transformed cells exposed to BUdR for two or three passages were unable to divide.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
